Have a sneer percolating in your system but not enough time/energy to make a whole post about it? Go forth and be mid - welcome to the Stubsack, your first port of call for learning fresh Awful you’ll near-instantly regret.
Any awful.systems sub may be subsneered in this subthread, techtakes or no.
If your sneer seems higher quality than you thought, feel free to cut’n’paste it into its own post — there’s no quota for posting and the bar really isn’t that high.
The post Xitter web has spawned so many “esoteric” right wing freaks, but there’s no appropriate sneer-space for them. I’m talking redscare-ish, reality challenged “culture critics” who write about everything but understand nothing. I’m talking about reply-guys who make the same 6 tweets about the same 3 subjects. They’re inescapable at this point, yet I don’t see them mocked (as much as they should be)
Like, there was one dude a while back who insisted that women couldn’t be surgeons because they didn’t believe in the moon or in stars? I think each and every one of these guys is uniquely fucked up and if I can’t escape them, I would love to sneer at them.
I kind of read wayyyyy too many preprints and some of that is the result of super briefly summarizing some things I have read recently. Here:
https://www.biorxiv.org/content/10.1101/2024.11.26.625518v2 poor codon optimality for your translation system leads to immunogenicity and activation of innate immune signaling in animal cells
As for length and super optimized proteins, it’s mostly about RIG proteins (see https://www.pnas.org/doi/10.1073/pnas.1005077107 for an old bit of a review) and the whole DRIP hypothesis about how short mismanufactured proteins are preferentially the source of presented antigens