• @sc_griffith
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    241 year ago

    I’ve now talked to some pretty well-qualified bio PHDs with expertise in stem cells, gene therapy, and genetics. While many of them were skeptical, none of them could point to any part of the proposed treatment process that definitely won’t work.

    absolutely classic crank shit

    • AcausalRobotGod
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      191 year ago

      I talked to some pretty well-qualified math PhDs with expertise in analytic number theory, algebraic number theory, and geometric number theory. While many of them were skeptical, none of them could point to any part of my proposed proof of Fermat’s Last Theorem that definitely won’t work.

      • @sc_griffith
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        181 year ago

        I’m a mathematician and this is exactly what I was imagining lmao

        • AcausalRobotGod
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          141 year ago

          so you’re saying I successfully simulated your thoughts, eh???

          • @sc_griffith
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            111 year ago

            wow. the ai really is going to get out of the box. if you as a lemmy poster can do this imagine how easy it will be for gpt5

            • AcausalRobotGod
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              121 year ago

              Wow, I mean, look at who you’re actually talking to here: I’m acausally reaching back in time to post this.

              • @sc_griffith
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                111 year ago

                what rats think their nightmare is: robot god condemns them to hell for eternity

                what their actual nightmare is: robot god shitposts on sneerclub

              • @selfMA
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                71 year ago

                ah, the long-awaited activitypub to future simulated hell API integration

                • David GerardOPMA
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                  81 year ago

                  isn’t that all fediverse software

    • @voracitude@lemmy.world
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      101 year ago

      I bet all of them pointed out the multifarious ways it could not work, though, and this guy heard “it shouldn’t work… but it might”.

      Frankly, good; he removed himself from the gene pool and we can probably learn something from his remains.

      That or we all get Kronenburg’d.

      • David GerardOPMA
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        131 year ago

        let’s be clear: this guy is not going to stop until he’s cooked his own brain out of his skull

    • @locallynonlinear
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      1 year ago

      I don’t think we would work out…

      So you’re saying I have a chance?

  • -dsr-
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    221 year ago

    Genetically altering IQ is more or less about flipping a sufficient number of IQ-decreasing variants to their IQ-increasing counterparts. This sounds overly simplified, but it’s surprisingly accurate; most of the variance in the genome is linear in nature, by which I mean the effect of a gene doesn’t usually depend on which other genes are present

    Contradicted by previous text in the same article (diabetes), not to mention have you even opened a college-level genetics text in the last decade?

    Anyway, I would encourage these people to flip their own genome a lot, except that they probably won’t take the minimum necessary precautions of doing so under observation in isolation. “Science is whatever people in white coats say it is, and I bought a nice white coat off Amazon!”

    • flere-imsaho
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      161 year ago

      most of the variance in the genome is linear in nature, by which I mean the effect of a gene doesn’t usually depend on which other genes are present

      that person seems homeschooled on absolute bullshit; basic high school biology course thirty-odd years ago was saying otherwise.

      • @selfMA
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        131 year ago

        that person seems homeschooled on absolute bullshit

        the yudkowsky tradition! cause skimming a book and reconstructing the rest of the knowledge on your gut feelings is a perfectly good substitute for going to fucking school, Eliezer

    • @Umbrias@beehaw.org
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      51 year ago

      Meanwhile actual discussions about biotech are more like

      “Is it feasible to get widespread changes in an organism we want or are biological systems hopelessly and fundamentally complex making this impossible?”

      The contrast amuses me.

  • @swlabr
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    211 year ago

    Hmm, how significant are we talking

    predicted IQ of about 900

    lol

  • @Amoeba_Girl
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    211 year ago

    In the course of my life, there have been a handful of times I discovered an idea that changed the way I thought about the world. The first occurred when I picked up Nick Bostr

    Alright thank you that’s enough.

    • @elmtonic@lemmy.world
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      151 year ago

      The first occurred when I picked up Nick Bostrom’s book “superintelligence” and realized that AI would utterly transform the world.

      “The first occurred when I picked up AI propaganda and realized the propaganda was true”

  • @GorillasAreForEating
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    1 year ago

    the cell’s ribosomes will transcribe mRNA into a protein. It’s a little bit like an executable file for biology.

    Also, because mRNA basically has root level access to your cells, your body doesn’t just shuttle it around and deliver it like the postal service. That would be a major security hazard.

    I am not saying plieotropy doesn’t exist. I’m saying it’s not as big of a deal as most people in the field assume it is.

    Genes determine a brain’s architectural prior just as a small amount of python code determines an ANN’s architectural prior, but the capabilities come only from scaling with compute and data (quantity and quality).

    When you’re entirely shameless about your Engineer’s Disease

  • AcausalRobotGod
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    191 year ago

    LOL – looking at the comments: “can somebody open a manifold market so I can get a sense of the probabilities?”

      • @selfMA
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        131 year ago

        It seems pretty obvious to me, and probably to many other people in the rationalist community, that if AGI goes well, every business that does not control AI or play a role in its production will become virtually worthless. Companies that have no hope of this are obviously overvalued, and those that might are probably undervalued (at least as a group).

        asking the important questions: if my god materializes upon the earth, how can I use that to make a profit?

        • @locallynonlinear
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          121 year ago

          Question: if the only thing that matter is using AGI, what powers the AGI? Does the AGI produce net positive energy to power the continued expansion of AGI? Does AGI break the law of conservation because… if it didn’t, it wouldn’t be AGI?

          • @selfMA
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            91 year ago

            n-nuh uh, my super strong AI god will invent cold fusion and nanotechnology and then it won’t need any resources at all, my m-m-mathematical calculations prove it!

            ok but how will the AI exist and exponentially multiply in a world where those things don’t already exist?

            y-you can’t say that to me! I’m telling poppy yud and he’s gonna bomb all your data centers!

  • @FermiEstimate@lemmy.world
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    181 year ago

    This is quite a grandiose plan for someone writing a LessWrong blog post. And there’s a decent chance it won’t work out for either technical reasons or because I can’t find the resources and talent to help me solve all the technical challenges.

    The phrase “technical reasons” is doing an absolutely majestic amount of work in this sentence.

    • David GerardOPMA
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      131 year ago

      don’t forget the bit where anyone who thinks this idea leads to racist stupidity just hates science

      • @GorillasAreForEating
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        121 year ago

        Looking forward to LW articles with titles like “Ashkenazification via engineered viruses as a solution for African poverty: here’s why it might work”

        • @bitofhope
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          91 year ago

          LWers love Ashkenazi so much they’ll happily have some even without the Ashke.

    • @locallynonlinear
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      81 year ago

      If only he were neither constrained by technical hurdles or resources, dang.

  • @elmtonic@lemmy.world
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    171 year ago

    From the comments:

    Effects of genes are complex. Knowing a gene is involved in intelligence doesn’t tell us what it does and what other effects it has. I wouldn’t accept any edits to my genome without the consequences being very well understood (or in a last-ditch effort to save my life). … Source: research career as a computational cognitive neuroscientist.

    OP:

    You don’t need to understand the causal mechanism of genes. Evolution has no clue what effects a gene is going to have, yet it can still optimize reproductive fitness. The entire field of machine learning works on black box optimization.

    Very casually putting evolution in the same category as modifying my own genes one at a time until I become Jimmy Neutron.

    Such a weird, myopic way of looking at everything. OP didn’t appear to consider the downsides brought up by the commenter at all, and just plowed straight on through to “evolution did without understanding so we can too.”

    • @NAXLAB@lemmy.world
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      131 year ago

      For real. Totally ignoring that evolution doesn’t work on individuals, only species over MILLIONS OF YEARS, and ALSO WE STILL HAVE ALZHEIMERS, CANCER, AND HARLEQUIN ICHTHYOSIS

    • mutual
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      101 year ago

      @elmtonic @dgerard “there is no difference between simulating an optimization process and actually carrying it out in the real world” is some top-tier rat shit, completely amazing

    • @Amoeba_Girl
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      51 year ago

      lol another rationalist personificating evolution, shocking

  • @shinigami3
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    141 year ago

    starts reading

    looks at the scrollbar size

    nope

  • @skillissuer@discuss.tchncs.de
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    111 year ago

    If not for that pesky FDA, rats would develop the most bizzare case of liver failure that medicine has ever seen and took over the world with their superior intellect, any day now, you’ll see

  • @bitofhope
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    101 year ago

    Credit where it’s due, I appreciate them leading with a TL;DR link to a summary. Unfortunately the summary was also too long and I didn’t read it. I’m happy for you though. Or sorry it happened.

  • @Soyweiser
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    1 year ago

    LLM’s are great you doubters, look this guy even used it to get unshadowbanned on twitter.

    Re the subject at hand 250+ upvotes oof. And once I again I feel the desire to write a 'gene editing to improve intelligence is immoral because of the higher depression risk that correlates with higher intelligence. But that would backfire very quickly (esp if we hook into other reasons why very smart people with no economic resources might even be extra depressed and poof we are back at eugenics and keeping the Morlocks poor away from intelligence improvements).

    Vague association with eugenics make some academics shy away

    This guys profile:

    currently doing independent research on gene therapy with an emphasis on intelligence enhancement.

    Gosh. (I honestly had not noticed these 2 quotes before I mentioned my trollpost + risk).

      • @Soyweiser
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        61 year ago

        I have thought that for the distopia a lot of the right fears brave new world fits a lot better than 1984. But that is unrelated to this.

  • @carlitoscohones
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    81 year ago

    I clicked the original LW link (not the archive link) and got a malware warning.

    • David GerardOPMA
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      131 year ago

      it was warning you the page contained lesswrong rationalism

      • @carlitoscohones
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        41 year ago

        I just tried it again. it’s my Orbi wi-fi thing, every time I follow a link to LW - “Orbit has blocked a malware attempt.”

        • @selfMA
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          71 year ago

          maybe whoever wrote the heuristic is also an anti-fan of rationalism and this is the form their sneering took

    • David GerardOPMA
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      81 year ago

      he’s even better in the comments, absolutely unhinged

      • AcausalRobotGod
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        61 year ago

        Maybe he’ll get to the point where he thinks you could do it by changing mouth bacteria to CRISPR your shit. Cure gum disease at the same time!